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Main » 2009 » September » 17 » Loxoribine InducesChronic Lymphocytic Leukemia B Cells to Traverse the Cell Cycle
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Loxoribine InducesChronic Lymphocytic Leukemia B Cells to Traverse the Cell Cycle
Loxoribine  Induces  Chronic  Lymphocytic  Leukemia B Cells  to Traverse 
the  Cell  Cycle

By Michael G. Goodman,  Susan B. Wormsley,  John C. Spinosa, and  Lawrence D. Piro
© 1994 by The  American  Society of Hematology.

Wood, Vol 84, No 10 (November 15). 1994: pp 3457-3464


Abstract


Leukemic B cells from a majority of patients with chronic lymphocytic  leukemia (CLL) enter the cell cycle upon  stimu- lation in vitro with loxoribine,  a potent 7,8-disubstituted guanine  ribonucleoside immunostimulant. In the absence of added  costimulants,  a proportion of these  cells  become  acti- vated and  undergo DNA synthesis  and  mitosis  accompanied by a marked increase in expression of an  array of cell surface activation antigens. The resultant  activated B-CLL  cells  ex- hibit greatly  enhanced  sensitivity to cycle-active  cytotoxic drugs.  This  approach may be of potential value in the ther- apy of CLL.

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Category: JOURNAL | Views: 471 | Added by: anis | Tags: Loxoribine Induces, chronic, Lymphocytic, Leukemia, B Cells, Cell Cycle | Rating: 0.0/0
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