Main | Registration | Login | RSSFriday, 2017-11-24, 6:07 AM

My site

Site menu
Login form
Section categories
JOURNAL [30]
Search
Main » 2009 » September » 16 » The environment and autoimmune thyroid diseases
3:22 PM
The environment and autoimmune thyroid diseases
The environment and autoimmune thyroid diseases

Mark F Prummel, Thea Strieder and Wilmar M Wiersinga

Department of Endocrinology and Metabolism, F5-171, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
(Correspondence should be addressed to M F Prummel; Email: m.f.prummel@amc.uva.nl)

European Journal of Endocrinology (2004) 150 605–618

Abstract

Genetic factors play an important role in the pathogenesis of autoimmune thyroid disease (AITD) and it has been calculated that 80% of the susceptibility to develop Graves’ disease is attributable to genes. The concordance rate for AITD among monozygotic twins is, however, well below 1 and environmental factors thus must play an important role. We have attempted to carry out a comprehensive review of all the environmental and hormonal risk factors thought to bring about AITD in genetically predisposed individuals. Low birth weight, iodine excess and deficiency, selenium deficiency, parity, oral contraceptive use, reproductive span, fetal microchimerism, stress, seasonal variation, allergy, smoking, radiation damage to the thyroid gland, viral and bacterial infections all play a role in the development of autoimmune thyroid disorders. The use of certain drugs (lithium, interferon-a, Campath-1H) also increases the risk of the development of autoimmunity against the thyroid gland. Further research is warranted into the importance of fetal microchimerism and of viral infections capable of mounting an endogenous interferon-a response.

Full PDF
Category: JOURNAL | Views: 348 | Added by: anis | Tags: environment, autoimmune, diseases, thyroid | Rating: 0.0/0
Total comments: 0
Name *:
Email *:
Code *:
Calendar
«  September 2009  »
SuMoTuWeThFrSa
  12345
6789101112
13141516171819
20212223242526
27282930
Entries archive
Our poll
Rate my site
Total of answers: 2
Site friends
  • Create your own site
  • Statistics

    Total online: 1
    Guests: 1
    Users: 0

    Copyright MyCorp © 2017